San Francisco 49ers forward Christian McCaffrey looked in top form since returning from an Achilles tendon injury early in the game against Buffalo. He had seven carries for 53 yards, including a long for 19 yards. He also caught two passes for 14 yards. But on McCaffrey’s seventh run, he gave up the play and slipped.

There was a noticeable limp and you could tell from the repetition that something went wrong. We won’t speculate on whether the injury has re-aggravated, but you can see for yourself:

After being examined by team trainers in the blue medical tent, McCaffrey left the field and went to the locker room. The 49ers are officially calling McCaffrey’s injury a knee injury. He could have been injured on the previous play:

You can’t help but feel bad for him after working so hard to get back. Making matters worse is that McCaffrey started out looking like himself.

According to the broadcast, McCaffrey was visibly frustrated on the sideline before heading to the locker room. We will provide any updates as they become available.

Linebacker Fred Warner was also questionable about returning due to cramps.