McCaffrey suffered what the 49ers called a knee injury and gave up his final carry. It was a sad scene for a player who worked so hard to come back. After a delay in the game penalty, the offense stalled. Jake Moody didn’t help matters, as his 45-yard field goal attempt went wide of the left net.

On the following play, Ji’Ayir Brown’s tackle attempt was one of the worst you’ll see this season. James Cook ran 65 yards untouched and the Bills took a 14-3 lead.

Jordan Mason gained 28 yards on first down and then another six on 3rd and 4. San Francisco made it into Buffalo territory again, but Purdy was sacked on 3rd and 9.

From an outcome perspective, it wasn’t the worst-case scenario. Pat O’Donnell pinned the Bills with a seemingly perfect punt at the three-yard line. This would be true if Josh Allen didn’t exist. Allen found Dalton Knox wide open for 39 yards. Cook ran for 18 and 11 yards on the next two plays. Within three plays, the Bills were in Niners territory.

Cook added another 13-yard run for good measure, and before you knew it, Buffalo was inside San Francisco’s 10-yard line. Allen threw a perfect pass to Mack Hollins for a touchdown, capping a 97-yard touchdown drive. It was obvious that the Bills were in a different class. This result made it 21:3.

The 49ers got into field goal range after Purdy found Jauan Jennings for a 17-yard gain. But Moody’s 55-yard field goal missed by a few yards, and the Niners had another fruitless drive before halftime.