49ers vs. Bills injury updates: Christian McCaffrey (knee) is out

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The San Francisco 49ers entered Sunday night’s game against the Buffalo Bills at Highmark Stadium without several key players. Defensive end Nick Bosa, cornerback Deommodore Lenoir and tackle Trent Williams were among seven players listed as inactive for the prime-time showdown.

Below are the latest in-game injuries for the 49ers.

RB Christian McCaffrey (knee, out)

The 49ers announced that running back Christian McCaffrey is questionable to return from a knee injury. McCaffrey left the game in the second quarter, was examined in the medical tent and then went to the locker room.

Update: During a television interview early in the second half, head coach Kyle Shanahan announced that McCaffrey would not return to the game.

The injury occurred on the following play. McCaffrey missed the first eight games of the season due to Achilles tendonitis.

DT Kevin Givens (chest, out)

The 49ers announced that defensive lineman Kevin Givens, who returned from a groin injury, is now unlikely to return to play after suffering a pectoral injury.

Update: The 49ers have ruled out Givens.

LB Fred Warner (cramps, questionable)

Linebacker Fred Warner is suffering from cramps and is listed as questionable to return to the game.

Update: Warner returned to the game.

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