OMAHA, Neb. – Pop Isaacs helped unranked Creighton upset No. 1 Kansas 76-63 on Wednesday night, scoring a season-high 27 points and matching his career high with six 3-pointers.

Kansas cut a 13-point deficit to one early in the second half, but Isaacs hit back-to-back three-pointers to extend the lead again as the Bluejays (6-3) pulled away and picked up their second win ever against a ranked opponent. In February, they beat Connecticut 85-66 in Omaha.

The Jayhawks (7-1) lost a regular-season game to an opponent not ranked in the conference for the first time in three years. Creighton appeared in 16 straight Associated Press polls before being eliminated this week after losses in three of its last four games.

At the final buzzer, students rushed the field as flames shot from the top of the goal standard.

Isaacs’ shooting performance overshadowed the duel between two of the best big men in the country, 7-foot-1 Ryan Kalkbrenner and the Jayhawks’ 7-2 Hunter Dickinson.

Isaacs was 10 of 15 from the field, including 6 of 9 on 3s, and posted seven rebounds and four assists, his best performance since transferring from Texas Tech in the offseason.

Kalkbrenner, who missed the Bluejays’ previous game with a lower-body injury, and Steven Ashworth, still feeling the effects of an ankle sprain from two weeks ago, each scored 17 points.

The Jayhawks struggled offensively and never led. Dajuan Harris had 15 points and AJ Storr and Zeke Mayo added 12 each for Kansas, a 36% margin.

The game was the 105th all-time for Kansas against an opponent not ranked No. 1 in the AP. Only two other times before Wednesday had the Jayhawks lost by double digits in such instances.

Information from ESPN Research and The Associated Press was used in this report.