Pop Isaacs scored 27 points, Ryan Kalkbrenner added 17 points and 10 rebounds and Creighton beat No. 1 Kansas 76-63 on Wednesday night in Omaha, Neb., the Jaywawks’ first loss of the season

Isaacs shot 6-for-9 from distance and added seven rebounds and four assists. His contested layup with 3:14 to play extended Creighton’s lead to 73-57 as the program earned its second win over a No. 1 team in school history. (The Bluejays defeated UConn 85-66 last season.)

Kalkbrenner, Creighton’s star center, missed Creighton’s win over Notre Dame on Saturday because of a lower-body injury and made a game-time decision on Wednesday.

Steven Ashworth contributed 17 points, eight rebounds and six assists as the Bluejays defeated Kansas (6-3) for the first time since 1949.

Dajuan Harris Jr. scored 15 points for Kansas (7-1). AJ Storr and Zeke Mayo each scored 12 points in the loss.

Harris hit a three-pointer and a layup to cap a 9-0 run early in the second half as Kansas cut its deficit to 41-40 with 17:31 left.

The Bluejays responded with a 10-0 run, capped by two 3-pointers from Isaacs and two free throws from Ashworth, extending Creighton’s lead to 51-40 with 15:58 left.

Ashworth hit a 3-pointer to cap the 7-0 lead and give the Bluejays a 65-53 lead with 9:26 to play. Kansas never got into single digits again.

Creighton built a 10-2 lead in just over three minutes thanks to two layups from Jamiya Neal and three-pointers from Isaacs and Jackson McAndrew.

The Bluejays continued the pressure thanks to their 3-point shooting, hitting five of their first eight attempts from deep to build a 21-11 lead with 11:36 left in the first half.

Creighton extended its lead to as many as 13 points in the first half.

–Field level media