Bills vs. Lions odds, prediction: NFL picks, player props

The Lions host the Bills on Sunday in one of the most anticipated games of the season.

Over the years, Bills quarterback Josh Allen has proven to be good at big games, even if he hasn’t won The Big Game yet.

Throughout his NFL career, Allen has made a habit of taking matters into his own hands in games like this.

In fact, he proved as much last Sunday when Allen ran for 82 yards and three touchdowns in a thrilling 44-42 loss to the Rams.

Bills vs Lions odds

team	Spread	Money line	In total
Bills	+2.5 (-110)	+118	Over 54.5 (-110)
Lions	-2.5 (-110)	-140	Below 54.5 (-110)

Odds provided by Caesars Sportsbook

4:25 p.m. ET, CBS

Three weeks earlier, Allen ran for 55 yards in the Bills’ win over the Chiefs, handing them their first loss.

In 10 career playoff games, Allen is averaging 56.3 rushing yards, including 146 yards on the ground in two postseason games last year.

Now, this isn’t a playoff game and the Bills don’t need to win on Sunday to clinch a second or third seed in the AFC.

But Allen and Co. undoubtedly want to defeat the team that is currently considered the Super Bowl favorite.

And of course, there’s the elusive MVP award that Allen is aiming for.

The Lions have not been an easy task at all for opposing quarterbacks this season, but they let them get out of the pocket and onto the field a bit.

Their 24.9 rushing yards allowed to quarterbacks in 2024 are the seventh-most in the NFL.

Bet on the Bills quarterback to score more tucks and runs than usual on Sunday.

The Game: Josh Allen Over 36.5 Rushing Yards (-115, DraftKings Sportsbook)

Dylan Svoboda is a versatile writer and analyst across many sports. He is particularly knowledgeable about the big three – MLB, NFL and NBA.