Leslie Charleson, known for her role on “General Hospital,” has died. She was 79.

The Daytime Emmy-nominated actress portrayed Monica Quartermaine on the soap opera for nearly 50 years.

“It is with a heavy heart that I announce the passing of my dear friend and colleague Leslie Charleson,” executive producer Frank Valentini confirmed on the show’s official Instagram account.

“The star of “GENERAL HOSPITAL” is leaving the daily show after 14 years”

“General Hospital” star Leslie Charleson has died at the age of 79. (Getty Images)

“Her enduring legacy spans nearly 50 years on General Hospital alone, and just as Monica was the heart of the Quartermaines, Leslie was a beloved matriarch of the entire cast and crew. I will miss our daily conversations, her quick wit and her incredible presence on set.

Do you like what you’re reading? CLICK HERE FOR MORE ENTERTAINMENT NEWS

“On behalf of everyone at General Hospital, my deepest condolences go out to their loved ones during this difficult time.”

Charleson’s cause of death has not yet been determined.

Charleson appeared in more than 2,000 episodes of General Hospital. (ABC photo archive)

She began working on the ABC drama in 1977, appearing in more than 2,000 episodes and was the show’s longest-serving cast member, according to IMDb.

CLICK HERE TO SIGN UP FOR THE ENTERTAINMENT NEWSLETTER

In addition to General Hospital, Charleson played Dr. Monica Quartermaine in General Hospital: Night Shift and Port Charles.

She began working in the industry in the ’60s with roles in As the World Turns and A Flame in the Wind. After appearing in more than 1,400 episodes of Love Is a Many Splendored Thing, she caught the attention of Ron Howard and played the role of Mrs. Dorothy Kimber in an episode of Happy Days.

Charleson began acting in the early 1960s, playing the role of Mrs. Dorothy Kimber in an episode of Happy Days. (ABC photo archive)

In addition to daytime television, her recent television appearances have included a role as herself in “Friends” and the role of a waitress in “The Return of the Muskrats.”

CLICK HERE TO GET THE FOX NEWS APP