The Notre Dame Fighting Irish enter as Goliath against David of the Indiana Hoosiers in the first round of the College Football Playoff.

No. 7 Notre Dame enters the race as a 7.5-point favorite at Fanatics Sportsbook and is -285 on the money line to advance to the second round, where the winner will face second-seeded Georgia.

Unlike most other college football bowl games, there will be no significant opt-outs or transfer portal players.

Indiana vs. Notre Dame odds

team	Spread	Money line	In total
Indiana	+7.5 (-115)	+230	Over 51.5 (-110)
Notre Dame	-7.5 (-105)	-285	Below 51.5 (-110)

Indiana vs. Notre Dame prediction

Friday, December 20, 8 p.m. ET, ABC/ESPN

Temperatures in the high 20s and wind gusts of over 15 mph are expected for this game, which will be played in South Bend, Indiana.

Snow showers are also forecast, so snow could be a significant factor.

We don’t expect either team to play their best under these conditions, especially No. 10 Indiana, which runs the ball 37.9 times per game, the 42nd-most in the FBS.

Additionally, these two defenses are some of the best college football has to offer.

Notre Dame allows 4.4 yards per play while Indiana allows 4.2 yards per play.

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Betting on college football?

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The Fighting Irish (11-1) ranked third nationally allowing just 13.6 points per game, while Indiana (11-1) ranked sixth with 14.7 points per game.

With two excellent defenses and potentially poor weather conditions looming in this game, this game lends itself to the Under an already high point total of 51.5.

Slam the Under here on a strong edge that could sink as the weather forecast clears.

PICK: Under 51.5 (-110, Fanatic)

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Why should you trust New York Post Betting?

Erich Richter is a Brazilian Jiu-Jitsu blue belt, but he has a black belt in MMA betting. During football season, he made huge profits in the player prop market during his final two seasons at The Post. Although he is constantly betting on distance, his return on investment since 2022 is 30.15 percent.