Michigan State football will travel west to begin its 2025 conference schedule.

The Big Ten released all football schedules for next season on Wednesday afternoon, and the Spartans will open conference play at USC on Sept. 20. It will be the first meeting between the football schools since 1990. USC joined the Big Ten in 2024, along with UCLA, Oregon and Washington.

MSU will begin the Big Ten schedule with two road games, including at Nebraska on Oct. 4, before returning home to play UCLA on Oct. 11. It will be the first meeting between Michigan State and UCLA in football since 1974.

Other highlights of MSU’s 2025 schedule include a home game against Michigan on October 25th and a return against Penn State at home on November 15th. For years, Penn State and Michigan State each played the last regular season game of the other season, but that was not a protected rivalry when the Big Ten expanded in 2024. The teams did not play in 2024 and last played in the 2023 season finale at Ford Field Detroit.