Week 15 of the NFL season begins with a matchup between NFC West rivals on “Thursday Night Football.”

The 7-6 Los Angeles Rams (+175 to win the division, +155 to make the playoffs) face the 6-7 San Francisco 49ers (18-1, 8-1), with both teams trying to win the First place-place Seattle Seahawks, who are 8-5. In Week 3, the Rams rallied from a double-digit deficit and overwhelmed the 49ers 27-24.

The Rams have won two straight and are coming off a wild 44-42 victory over the Buffalo Bills in Week 14. The injury-plagued 49ers had lost three straight games before defeating the Chicago Bears 38-13 last week.

The action at Levi’s Stadium in Santa Clara begins at 8:15 p.m. ET on Prime Video.

Odds are current as of publication, courtesy of ESPN BET

---

Game lines

Spread: 49ers -3 (Opened 49ers -2.5)
Money line: 49ers -145, Rams +125
Over/Under: 49.5 (open 48.5)

Distribution in the first half: 49ers -1.5 (-105), Rams +1.5 (-115)
49ers total points: 25.5 (above -110/below -120)
Rams total points: 23.5 (above -105/below -125)

Matchup Predictor (according to ESPN Analytics): 49ers 60.8% chance of winning

---

The props

Passing by

Matthew Stafford’s total passing yards: 249.5 (Over +100/Under -130)
Stafford’s total passing TDs: 1.5 (above -135/below +105)
Brock Purdy’s total passing yards: 249.5 (Over -135/Under +105)
Purdy’s total passing TDs: 1.5 (above -155/below +120)

Rush

Kyren Williams Total Rushing Yards: 70+ (above -135)
Brock Purdy Total Rushing Yards: 20+ (About -130)

Reception

Puka Nacua total receiving yards: 89.5 (above -125/below -105)
Cooper Kupp total receiving yards: 69.5 (Over +105/Under -135)
Jauan Jennings total receiving yards: 69.5 (above -115/below -115)
George Kittle’s total receiving yards: 59.5 (above -115/below -115)
Deebo Samuel Sr. total receiving yards: 49.5 (above -110/below -115)

---

Joe Fortenbaugh’s choice

Brock Purdy UNDER 20.5 rushing yards

That number is a bit high, thanks in part to Purdy’s season-high 10 rushing attempts against the Rams in Week 3, which resulted in 41 rushing yards. So why are we thinking about the bottom here? Simply. The status of stalwart left tackle Trent Williams, who has missed each of the last three games with an ankle injury. Here’s how Purdy performed this season with and without Trent Williams on the field:

With Williams: 5.1 rushing attempts, 26.7 rushing yards per game.
Without Williams: 3.5 rushing attempts, 7.5 rushing yards per game.

Purdy has only surpassed that mark once in his last four starts as he slowed down rushing attempts late in the season. With Williams officially inactive for this match, let’s take a shot at the minors.

---

Betting trends

Courtesy of ESPN Research

• The Rams are 6-7 against the spread; the 49ers are 5-8 ATS.

• The Rams are 0-3 ATS as a road underdog this season (4-11-1 ATS over the last three seasons). However, they have won and played a total of three away games in a row.

• The 49ers are 1-7 ATS against teams with winning records this season (0-5 ATS in the last five).

• The Rams are on a short streak of 13-4-1 ATS under Sean McVay, including 8-1 ATS since 2021 and 4-0 ATS since the start of last season.

• The Rams are 27-13 ATS in December or later under McVay.

• Four straight meetings between the Rams and 49ers have exceeded the total. The Rams have played three straight meetings, although Kyle Shanahan is 10-6 ATS against McVay including the playoffs.

---

More from ESPN