Golden Globes, take note – Nikki Glaser is here to host.

Glaser, 40, opened the show with a reference to weight-loss drugs and proclaimed it was “Ozempic’s biggest night.”

While on stage live at the Beverly Hilton Hotel in Beverly Hills, California, Glaser praised Zendaya for her role in “Challengers,” about the tennis ace in a love triangle with her husband and ex-boyfriend.

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“This movie was more sexually charged than Diddy’s credit card,” Glaser said. “I know…I’m upset too. The afterparty won’t be so good.”

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She joked that Stanley Tucci should be hosting now. “There is no baby oil this year, just olive oil,” Glaser said.

On March 25, Sean “Diddy” Combs’ homes in Los Angeles and Miami were searched in connection with a federal human trafficking investigation, officials confirmed to Fox News Digital at the time.

During the search, authorities allegedly seized various “Freak Off” supplies, including narcotics and more than 1,000 bottles of baby oil and lubricant, according to the federal indictment.

As we counted down the names of nominated films, a top star was also thrown into Glaser’s mix.

“‘Wicked,’ ‘Queer,’ ‘Nightbitch’…these aren’t just words Ben Affleck screams when he orgasms,” Glaser said.

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Affleck is in the middle of a divorce from his second wife Jennifer Lopez.

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Before the show, Glaser recalled 22 years of hard work in the industry to get where she is today.

“I started ‘Last Comic Standing’ when I was in college,” Glaser told CBS before detailing her shows on MTV and Comedy Central.

It was former Golden Globes host Ricky Gervais who gave her important hosting advice.

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“You’re going to do great,” she remembered Gervais saying. “You’re not one of them.”