The Green Bay Packers will be without four preferred starters on defense when they face the New Orleans Saints in Week 16 on Monday Night Football.

Linebacker Quay Walker, cornerback Jaire Alexander, rookie defensive back Javon Bullard and rookie safety Evan Williams are all inactive against the Saints. Walker and Bullard were sidelined in Saturday’s latest injury report with ankle injuries, while Alexander is still not physically ready to return from a knee injury he suffered in late October. Williams suffered a quadriceps injury late in the week and was listed as questionable on the final injury report.

In prime time, an undermanned Saints offense faces a suddenly undermanned Packers defense.

Isaiah McDuffie, Edgerrin Cooper and Eric Wilson should handle most of the snaps at linebacker, with Ty’Ron Hopper available as a backup option. In the defensive backfield, expect Keisean Nixon to start with Carrington Valentine and Eric Stokes on the outside, and Zayne Anderson could make a first career start alongside Xavier McKinney at the safety position.

Receiver Malik Heath and offensive lineman Jacob Monk are both healthy scratches for the second straight week.

The Saints will be without quarterback Derek Carr, running back Alvin Kamara, receiver Chris Olave, receiver Rashid Shaheed and tight end Taysom Hill. Former Packer Marquez Valdes-Scantling is also inactive.

Packers inactive in Week 16

LB Quay Walker
WR Malik Heath
S Javon Bullard
CB Jaire Alexander
S Evan Williams
OL Jacob Monk

Saints inactive in Week 16

QB Derek Carr
WR Marquez Valdes-Scantling
RB Alvin Kamara
DT Nathan Shepherd
DT Christian Boyd