Millions of Americans can expect wintry weather this weekend as a storm brings ice, snow and rain to the central Plains, the Ohio Valley and the Mid-Atlantic.

According to the National Weather Service, winter weather will begin across the Plains late Saturday before reaching the Mid-Atlantic on Sunday. Blizzard and whiteout conditions are expected in the central plains, making driving either dangerous or impossible without risk of stranding.

At least 8 inches of snow is expected in Indiana and central Kansas, areas that could see the highest snowfall in at least a decade, the service reported.

Dangerous sleet or freezing rain is forecast between eastern Kansas and the Ozarks toward the Ohio Valley, forecasters said. Meanwhile, the central Appalachians will face freezing rain and ice, creating the risk of power outages and dangerous travel.