Will 49ers RB play Rams tonight?

When injury fever hits the 49ers, it’s going to take a good dose.

San Francisco, plagued by injuries all season, didn’t hire a good exterminator before the 2024 season and lost key contributors seemingly at every turn this year. The running back room has been hit particularly hard, particularly with injuries to Christian McCaffrey, Jordan Mason and Elijah Mitchell.

Putting the next man up mentality to the test, the 49ers are still a few running back problems away from getting fans out of the stands to suit up.

Until Isaac Guerendo showed up. The 2024 fourth-round rookie pick entered action on Sunday in Week 14 and dominated the Bears with 128 total yards and two touchdowns. However, he dropped out and did not return, clouding his status for Thursday night.

After a few days of uncertainty, anyone worried about the running back’s status can breathe a sigh of relief.

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Here’s the latest on Guerendo’s status for Week 15 on Thursday Night Football.

Update on Isaac Guerendo’s injury

Guerendo wants to play against the Rams on Thursday nightsaid ESPN’s Adam Schefter.

He left Sunday’s win with what head coach Kyle Shanahan called a possible ankle sprain. Guerendo didn’t seem too worried about his availability for “Thursday Night Football,” saying via NBC Sports Bay Area after the game that the team was just being cautious.

It’s not hard to see the argument for a little more rest and recovery for Guerendo, considering he left in the fourth quarter when San Francisco led 31-13 with just under 11 minutes left. No one will blame the 49ers for being more cautious given their bad luck in 2024.

Regardless, it felt like an uphill battle for Guerendo to play all week, which was a quick turnaround after Sunday’s game. He was listed as DNP on Monday and Tuesday before being limited during walk-through practice on Wednesday.

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Will 49ers RB play Rams tonight?

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